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PSG Center for Molecular Medicine and Therapeutics was established in May 2009 under the aegis of the PSG Trust. It is located on the fourth floor of the new academic building at the PSG IMSR campus. The center fosters high end molecular research to understand the molecular mechanisms of various diseases.

Vision

Our vision is to build a healthier community by bringing active minds and rigorous research together in the crucible of collaborative clime.

Mission

We promote health by researching the intersection of fundamental and clinical, health and disease, cellular and community, evidence and practice, translation and treatment.

Values

  • Integrity
  • Vision
  • Sharing
  • Perseverance
  • Lateral thinking

About Us

PSG CMMT is equipped with faculty from diverse backgrounds.

Research

Extramural Funding
Ramalingam Sankaran, MD – Professor and Head, PSG CMMT

Female Genital Tuberculosis: An Epidemiological study and development of a novel endometrium specific biomarker.

Funding agency: ICMR

Persistent Organic Pollutants and type 2 diabetes mellitus in a rural population –a case control study

Funding agency: ICMR-University of Minnesota


Development of a Novel serum based biomarker for early diagnosis of preeclampsia (Jointly with PSG College of Technology)

Funding agency: IBM Computers

Sudha Ramalingam, MD Associate Professor, PSG CMMT
Genotype Phenotype correlation of a novel G protein coupled receptor kinase protein (GRK5) in cardiac failure patients and their response to beta blocker therapy

Funding agency: Department of Biotechnology-Rapid Grant for Young Investigators

Association of PER3 clock gene polymorphisms in breast cancer

Funding agency ICMR-STS project fund

Peroxisome Proliferator Activator Receptor Gamma (PPAR _) polymorphism Implications in risk prediction for Gestational Diabetes Mellitus and Fetal outcome in Indian Women

Funding agency: Dr. Thangavelu memorial research award and grant

Thiagarajan Sairam. Ph D, Assistant Professor PSG CMMT
Expression of Toll- like Receptor Signaling Pathway Genes in Rheumatoid Arthritis

Funding agency: Department of Biotechnology-Rapid Grant for Young Investigators

Modulation of Indoleamine 2,3 dioxygenase (IDO) activity of Dendritic Cells by potential factors of Rheumatoid Arthritis Serum

Funding agency: DBT-Indo-Queensland early career fellowship

Intramural projects

Ramalingam Sankaran

Association of PPAR gamma with therapeutic response to glitazones – Post Graduate thesis project in Pharmacology

Association of PER3 gene polymorphisms and wakefulness in adults

Sudha Ramalingam

Association of PPAR gamma polymorphism in preeclampsia

Type 2 diabetes mellitus and clock gene polymorphisms

Does PTPN22 play a role in susceptibility to tuberculosis in Indian patients? A hospital based case control study from a tertiary care hospital in South India?

Thiagarajan Sairam

Role of Mudakatthan on Toll like receptor 2 expression

Awards & Fellowships

Ramalingam Sankaran

Post Doctoral Fellowship – Pharmacogenetics, Stanford Medical School, USA

Deans Fellowship- Stanford University

Sudha Ramalingam

Post Doctoral Fellowship Clinical molecular Genetics, Stanford Medical school, USA

Post Doctoral Fellowship – Genetic Epidemiology, Pritzker school of Medicine, University of Chicago, USA.

DBT Travel grant – To travel to Montreal, Canada for ICHG-ASHG meet

Dr. Thangavelu memorial research award and grant for under graduate research work

Thiagarajan Sairam

Indo- Queensland Early career fellowship at University of Queensland

Publications

Ramalingam Sankaran

  • Studies on pharmacological effects of Russell’s viper and Saw-scaled viper venom and its neutralization by chicken egg yolk antibodies. S. Meenatchisundarama, G. Parameswaria, A. Michael , S. Ramalingam. Int Immunopharmacol (2008), doi:10.1016/j.intimp.2008.03.017
  • Neutralization of the pharmacological effects of Cobra and Krait venoms by chicken egg yolk antibodies. Meenatchisundaram S, Parameswari G, Michael A, Ramalingam S. Toxicon. 2008 Aug 1; 52(2):221-7. Epub 2008 Jun 3
  • Impact of supplementation of food based antioxidant mix on the antioxidant status of selected breast cancer patients. Kowsalya S, Ramalingam S, Ithyamalar S.Ind J Nutr Dietet.2008 .45, 257
  • Validity: Is Thy Name Research? Case Commentary . S Ramalingam, Sudha Ramalingam. Asian Bioethics Review 1 (3) Sep 2009, 288-291
  • Haim Munk syndrome and Papillon Lefevre syndrome–allelic mutations in cathepsin C with variation in phenotype. Reena Rai, S Thiagarajan, Soumya Mohandas, Karthika Natarajan, C Shanmuga Sekar, S Ramalingam . International journal of dermatology. 05/2010; 49(5):541-3

Sudha Ramalingam

  • Sudha Ramalingam, Murali A, Seethalakshmi A, Deepa R, Meera, Rajendiran G: Cardiovascular disease risk factors in a tribal population of Nilgiris: Accepted for publication in Nat.J.Res.Com.Med.1 (2 ): 90-94: 2012
  • Grassi MA, Tikhimorov.A, Sudha Ramalingam, Below JE, Cox NJ, Nicolae DL. Replication Analysis for Severe Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2012 Mar 16. [Epub ahead of print] PMID: 22427569
  • Grassi MA, Tikhomirov A, Sudha Ramalingam S, Below JE, Cox NJ, Nicolae DL. Genome-wide Meta- analysis for Severe Diabetic Retinopathy. Hum Mol Genet. 2011 Jun 15; 20(12):2472-81. Epub 2011 Mar 26. PMID: 21441570
  • Sudha Ramalingam S.Nivedhitha, Pondivya, P.Madhurima, R.Poonguzhali:Knowledge and Attitude about Breast Cancer and Breast Self Examination among school teachers in an urban area of Coimbatore Asian Students Medical Journal (In Press)
  • Anil Mathew, Prince G, Remees Raja, John Matthai, Sudha Ramalingam, Risk factors of asthma in school going children-an Urban South Indian Study: Nepal Journal of Epidemiology: Vol 2 issue 1 2012(In Press)
  • Loganathan N, Sudha Ramalingam, Ravishankar D, Shivakumar S :Co-Infection of Malaria and Leptospirosis – A Hospital based study from South India: Accepted for publication in National Journal for research in Community Medicine (April 2012)
  • Sudha Ramalingam: Undergraduate Medical Research – The Essential Domain: Review Article: Nat.J.Res.Com.Med.1 (1):01-60, 2012
  • Mallikarjuna VV, Sudha Ramalingam. Promoting under graduate research-role of Student research forums in medical colleges. Int J StudRes2011;1(4):143-4.doi:http://dx.doi.org/10.5549/IJSR.1.4.143-144
  • Anil Chankaramangalam Mathew, Shaijin S, Renu David, Sudha Ramalingam, Srikanth K Parental atopy and exposure to pets on asthma-A hospital based case control study : Int J Prev Med. 2011 Jul;2(3):151-7. PMID: 21811657
  • A.C. Mathew, S. Shaijin, R. David, Sudha Ramalingam, K. Srikanth and Ma. Yunsheng: Association Between Obesity and Asthma among Adults: A Hospital Based Case-Control Study: Asian Journal of Epidemiology Vol:2, Issue:2, 33-43, 2009
  • Sankaran R, Sudha Ramalingam: Validity is thy name research? Case commentary, Asian Bioethics Review: Vol Number 3 (2009)
  • Mathew A, Jose A, Soubhya TB, Shankar R, Sudha Ramalingam , Chacko TB, Rajendiran G, Vaidyanathan C, Bhuvaneswaran JS and Ma Y. Association of physical inactivity with the risk of coronary heart disease. South Asian Journal of Preventive Cardiology. 2009:April
  • Iris Schrijver, Wikrom Karnsakul, Sudha Ramalingam, Ramalingam Sankaran, Chanin Limwongse , Richard Moss, Phyllis Gardner; Novel contributions to the Asian CFTR mutation spectrum: genotype and phenotype in Thai patients with cystic fibrosis. American Journal of Medical Genetics Volume 133A, Issue 1 , 2005, Pages 103 – 105
  • Iris Schrijver, Sudha Ramalingam, Ramalingam Sankaran, Steve Swanson, Charles L M Dunlop, Steve Keiles, E.Robert Wassman, Richard Moss ,J Oehlert, Phyllis Gardner, Anja Kammesheidt Comprehensive CFTR Mutation analysis in a large group of Hispanics; Novel mutations and assessment of a population-specific mutation spectrum;.; Journal of Molecular Diagnostics: Vol 7;No 2; May 2005

Thiagarajan Sairam

  • Jeya, M., Thiagarajan, S., & Gunasakeran, P. (2005) Improvement of xylanase production in solid state fermentation by alkali tolerant Aspergillus versicolor MKU3. Letters in Applied Microbiology. 41, 175-178
  • Thiagarajan, S., Jeya, M. & Gunasakeran, P. (2005) Improvement of xylanase production in solid state fermentation by alkali tolerant Aspergillus fumigatus MKU1 using fractional factorial design. Indian Journal of Experimental Biology. 43, 887-891
  • Thiagarajan, S., Jeya, M. & Gunasakeran, P. (2006) Purification and characterization of a high molecular weight endoxylanase from the solid-state culture of an alkalitolerant Aspergillus fumigatus MKU1. World journal of Microbiology and Biotechnology. 22 (5),487-492
  • Thiagarajan, S., Jeya, M. & Gunasakeran, P. (2006) Purification and characterization of an endoxylanase from the solid-state culture of an alkalitolerant Aspergillus fumigatus MKU1. Indian Journal of Biotechnology. 5, 351-356
  • Jeya, M. Thiagarajan, S., Jung-Kul Lee & Gunasakeran, P. (2009) Molecular cloning of GH10 and GH11 xylanase genes from Aspergillus versicolor MKU3 by genome walking PCR. Biotechnology and Bioprocess Engineering. 14(1), 13–19
  • Jeya, M. Thiagarajan, S., Jung-Kul Lee & Gunasakeran, P. (2009) Cloning and Expression GH11 Xylanase Gene from Aspergillus fumigatus MKU1 in Pichia pastoris. Journal of Bioscience and Bioengineering. 108(1), 24 -29
  • Reena Rai., Thiagarajan, S., Karthika Natarajan., Soumya Mohandas., Shanmuga Sekar C., Ramalingam.S. (2009) Haim munk syndrome and papillon lefevre syndrome – allelic mutations in cathepsin c with variation in phenotype. International Journal of Dermatology. 49(5), 541-543